2β,3β-Dihydroxy-27-norolean-13-ene-23,28-dioic acid
polygalic acid
CAS: 1260-04-4
Molecular Formula: C29H44O6
2β,3β-Dihydroxy-27-norolean-13-ene-23,28-dioic acid - Names and Identifiers
2β,3β-Dihydroxy-27-norolean-13-ene-23,28-dioic acid - Physico-chemical Properties
| Molecular Formula | C29H44O6 |
| Molar Mass | 488.66 |
| Density | 1.25 |
| Melting Point | 299-301℃ |
| Boling Point | 637.6±55.0 °C(Predicted) |
| pKa | 4.30±0.70(Predicted) |
| Physical and Chemical Properties | From tenuifolia Willd, a perennial herbaceous plant of Polygala family, Polygala. The root |
2β,3β-Dihydroxy-27-norolean-13-ene-23,28-dioic acid - References
| Overview | saponins from the root or root bark of Polygalaceae, which contains a variety of triterpene saponins, with calm, expectorant and other effects, commonly used in medicine and health food. This information is compiled by Sun Xiaoxia. |
| Source | Polygala tenuifolia saponin is an active substance extracted from Polygala tenuifolia. Polygala tenuifolia, perennial dwarf herb, about 30cm in height, stems clustered, slender, subhairless. Leaves alternate, linear or narrowly linear, subsessile. Racemose, flowers biased to one side; Flowers green white with purple, Sepals 5, outer wheel 3 small, inner wheel 2-petal-shaped; Petals 3, confluent in lower part, middle petal was longoseptically like, apical with filiform appendages; Stamens 8, base of filament connate into sheath-like. Capsule flat, obovoid, margin with narrow wings. Seeds were flat, black, densely covered with fine white hair. The root is thin cylindrical, curved long 3~10cm, 0.2~1cm in diameter. The surface is gray-brown or gray-yellow, with most deep-seated transverse furrows or transverse fissures, and the old roots are more dense and nodular. Mainly produced in Shanxi, Shaanxi, Jilin, Henan and other provinces. Chemical Characterization of Polygala tenuifolia (1) hand-cut slice, 1 drop of concentrated sulfuric acid, purplish red; Potassium hydroxide solution, bright yellow. (2) take 0.5g of powder, Add 10ml of distilled water, and shake vigorously for 1 minute to generate permanent foam, which does not disappear within 10 minutes (check saponin). Take 0.2g of powder by thin layer chromatography, add 5ml of methanol, warm soak for 30 minutes, filter, and concentrate the filtrate to 1ml for spotting. Adsorbent: silica gel G (Qingdao) 3G, 10ml of distilled water was added to make a plate, dried and activated at 110 ° C. For 2 hours. Spread with n-butanol-acetic acid-water (5:1:4) at a distance of 10cm. Compared with the Polygala tenuifolia saponin A and Polygala tenuifolia saponin B samples, the blue spots were observed under an ultraviolet lamp (254nm). Figure 1: Polygala |
| pharmacological action | 1. Expectorant effect of Polygala tenuifolia saponin has a stimulating effect on the pharyngeal mucosa, can increase its secretion, and has a mild irritation to the gastrointestinal mucosa, causing mild Nausea, thus reflex increased bronchial secretion and expectorant effect. It has been reported that intragastric administration of polygalic saponin in anesthetized dogs does not increase tracheal secretion, which may be caused by the animals being under anesthesia. 2. Hemolytic effect Polygala contains saponins, intravenous administration has the effect of dissolving red blood cells. Other effects of Polygala Saponins also have sedative and increased uterine contraction and muscle tone. |
| extraction method | 1. Microwave-field synergistic extraction method FIG. 2: extract and weigh 30g of Polygala tenuifolia powder, heat and reflux with 150mL petroleum ether for 1H for degreasing, volatilize the dry solvent, and add 95% ethanol of the experimental dosage, with microwave radiation 30s, after an interval of 1min radiation 30s, repeat the interval radiation to the total radiation time to reach the experimental time, filtering. The extraction was repeated once under the same conditions. The extract was vacuum concentrated to about 15ml with a rotary evaporator, and 30ml of acetone-ether mixture was slowly added to form a pale yellow precipitate, which was filtered and the precipitate was vacuum dried to obtain a crude product of Polygala tenuifolia saponin. Direct heating extraction method to weigh 30g Polygala powder, with 150mL petroleum ether reflux heat 1H degreasing, volatile dry solvent, add 300mL 95% ethanol, reflux extraction 1H, filtration. The extraction was repeated once under the same conditions. The extract was vacuum concentrated to about 15ml with a rotary evaporator, and 30ml of acetone-ether mixture was slowly added to form a pale yellow precipitate, which was filtered and the precipitate was vacuum dried to obtain a crude product of Polygala tenuifolia saponin. |
| Use | for content determination/identification/pharmacological experiments. Pharmacological Efficacy: has a strong expectorant effect; Inhibition of cyclic adenosine monophosphate dienzyme; Can enhance the physical and intellectual properties of animals; Has a strong hemolytic effect, it has an inhibitory effect on the aldehyde and ketone reductase. In addition, there are anti-mutation, anti-cancer, sedative, anticonvulsant, anti-edema and diuretic effects. |
Last Update：2024-04-09 19:05:22
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